Youssef En-Nesyri scored twice as Europa League specialists Sevilla capitalised on a dreadful defensive display from Manchester United to dump the Premier League side out of the competition with a convincing quarterfinal second leg win.
Starting the decider level at 2-2 after scoring two late goals in the first leg at Old Trafford, the hosts went ahead for the first time in the tie when En-Nesyri fired past goalkeeper David de Gea, who had begun a blundering performance by playing a poor pass to Harry Maguire to allow Sevilla to pounce.
United coach Erik ten Hag sent top scorer Marcus Rashford – returning from injury – and Luke Shaw on at the break, but the action had barely restarted when Loic Bade headed over De Gea from Ivan Rakitic’s corner.
De Gea then gifted Sevilla a late third when he needlessly raced out of his penalty area towards a long ball, playing possession straight to the feet of the grateful En-Nesyri, who sent a precise finish from distance into the back of the empty net.
The comprehensive victory gave Sevilla a 5-2 victory on aggregate and revisited the frailties United showed during the early part of the season and in their 7-0 domestic mauling at Liverpool.
United now cannot complete the treble of trophies they had been hoping for following their Carabao Cup triumph over Newcastle in February.
Third-placed in the English top flight after being left behind by top two Arsenal and Manchester City, they play Brighton & Hove Albion in the FA Cup semifinals at Wembley Stadium on Sunday.
Sevilla have earned the right to play Juventus in a two-legged semi-final, with the matches taking place on May 11 and 18 May after the Italian giants saw off Sporting 2-1 on aggregate in their quarterfinal in Lisbon.